Polymorphism: HLA-DRB1 13 generic DRB1 alleles
Location: 6p21.3
Factor:
- Symbol: HLA-DRB1
- Name: major histocompatibility complex, class II, DR beta 1
- Entrez ID: 3123
- Ensembl ID: ENSG00000196126
Factors:
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
(
3123
/
ENSG00000196126
)
Description:
Candidate gene
Ethnicity:
French
Age of cases: 100+ and 90+ siblings
Shorter lived allele: non-DR7 alleles
Longer lived allele: DR7
Statistics
- Number of cases/controls: 152 vs 2950 (initial)
| 208 vs original 2950 (replication)
- Odds ratio: 1.72
- p-value:
0.01
- Significant: Yes
Study Design
- Classifications:
Longevity-Associated
- Study type: Candidate Region/Gene
- Technology: Reverse dot-blot (Murex Diagnostics Inno-Lipa DRB1)
Reference:
9425225: HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity.
Choice: Curate_Johnny
Created: June 30, 2013, 11:53 p.m.
Updated: Aug. 8, 2014, 1:05 p.m.
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