Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
rs2251101 IDE 1.88 0.0011 829 vs 1033 — Australian, Caucasian Mixed — — Candidate Region/Gene 18448515
55 (L/M) PON1 0.94 0.44 308 vs 579 Italian, 296 vs 296 Irish — Irish, Italian Italian 100.8 years, Irish 89.8 years — — Candidate Region/Gene 15050299
rs12770830 HSPA14 1.35 0.011 1,089 vs 736 1,613 vs 1,104 Danish, German 92-93 Danish, 95–110 German — — — 22234866
rs1685354 UCP3 — 0.762 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
rs647126 UCP3 — 0.447 908 vs 708 — Danish 93 — — Candidate Region/Gene 22743239
SV-6 CLU — 1.0 49 vs 27 vs 20 — Greek, Italian 99–107 — — Candidate Region/Gene 16804001
rs1800629 TNF — 1.0 119 vs 118 — Jordanian Mean age 90.2 — — Candidate Region/Gene 20518833
rs1043618 HSP70-A1A — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs6457452 HSP70-A1B — 1.0 347 vs 238 — American, Ashkenazi Jewish Minimum age 100 — — Candidate Region/Gene 17027907
rs708272 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
rs5882 CETP — 1.0 12 vs 190 vs 105 — Greek 99-111 — — Candidate Region/Gene 23389097
H63D HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
S65C HFE — 1.0 35 vs 106 — 91-105 — — Candidate Region/Gene 11857056
- Insulin signaling pathway (IIS) — 0.01 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
- Telomere maintenance pathway (TM) — 0.02 403 vs 1670 — European 90-103 — — Genome-Wide Association Study 22113349
rs3758391 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs1885472 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs2273773 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs10997870 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs2234975 SIRT1 — 1.0 386 vs 640 vs 547 — German Mean age 101 — — Candidate Region/Gene 16257164
rs1801274 FCGR2A — 1.0 408 vs 446 vs 454 — German Centenarians — — Candidate Region/Gene 16893392
3p24-22 3p24-22 — 0.037 3953 — American Minimum age 98 — — Genome-Wide Association Study 20824210
C150T mtDNA L2 — 1.0 556 vs. 403 — Chinese 90-108 — — Mitochondrial Haplogroup 21262335
rs854560 PON1 — 1.0 579 vs 308 — Italian Over 100 — — Candidate Region/Gene 12082503
192/55 loci PON1 — 0.01 579 vs 308 — Italian Over 100 — R+M+ Candidate Region/Gene 12082503
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  • 25 of 1635 variants