• name effect species mean median maximum
    cyc1 mutation cyc1 mutants have a reduced growth rate, a reduced reactive oxygen species production, and are long-lived [17081785].
    PaDnm1:ble Dnm1 disruption in wild-type extends mean and maximum lifespan by 377 and 329% and its disruption in long-lived grisea mutants prolongs mean and maximum lifespan by 1009 and over 1090% (survival was not followed to the end) [17173038]. +377 +329
    Grisea mutation In Grisea (AFUA_1G13190) loss of function mutants, senescence is delayed two-fold [8804410]. Grisea disruption extends mean and maximum lifespan by 195 and 210% [17173038]. Grisea mutant has altered norphology and defects in formation of female gametangia [9380708]. +195 +210
    COX5 deletion Disruption of the nuclear COX5 gene delays senescence, increase longevity between 7- and 15-fold (in 30 tested isolates) and the onset of senescence is not associated by accumulation of senescence-specific mtDNA molecules. COX5 deletion results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species and the prevention of the accumulation of several senescence-specific mitochondrial DNA molecules [10759557].
    COX1 deletion Deletion of mobile group II intron (intron alpha) from COX1 doubles lifespan and prevents accumulation of senescence-associated DNA concatemer corresponding to this of the mitochondrial genome [10330149]. Deletion encompassing COX1's intron alpha and its upstream exon abolishes the senescence process entirely [2999848].
    • 5 interventions
    Interventions are an extension of GenAge and GenDR.