Interventions

  • name effect species mean median maximum
    Moderate DR Moderate DR is the restriction of glucose concentration from 2% (*ad libitum*) to 0.5%, which extends the mean, median and maximum replicative lifespan by 45 - 52%, 43 - 50% and 50 - 52%, respectively [23172144] Moderate DR increases vacuolar acidity in young cells and prevents the decline of vacuolar acidity in aging cells. DR also suppresses mitochondrial dysfunciton of aged cells (21 divisions) in a V-ATPase-dependent manner [23172144]. Constitutively activating PKA signaling by deleting the Ras GTPase-activating protein IRA2 reduces vacuolar acidity and accelerates the development of mitochondrial dysfunction in aging cells and prevents DR-mediated enhancement of vacuolar acidity and suppression of mitochondrial dysfunction [23172144]. Lifespan extension by DR is prevented in a strain lacking V-ATPase activity [23172144]. Yeast +45.2 to +51.7 +42.9 to +50.0 +50.0 to +52.0
    Methionine restriction Restriction of the methionine content in the culture extends mean and maximum lifespan by up to 29 and 16% (1/10 methionine content) [15141092]. Yeast +29 +16
    • 2 interventions
    Interventions are an extension of GenAge and GenDR.