Interventions

  • name effect species mean median maximum
    Homozygous Gh1 anti-sense transgene Animals carrying two copies of a Gh1 anti-sense transgene (tg/tg) have a slighlty shorter lifespan (by 5-10%) compared to -/- animals. tg/tg animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928]. Rat -5 to -10
    Heterozygous Gh1 anti-sense transgene Animals carrying a single copy of an anti-sense Gh1 transgene (tg/-) live on average 7-10% longer. tg/- animals are dwarfs and exhibit reduced levels of serum IGF1 [12057928]. Rat +7 to +10
    • 2 interventions
    Interventions are an extension of GenAge and GenDR.