Interventions

  • name effect species mean median maximum
    Sir2 knockdown A diet-dependent lifespan phenotype of dSir2 knockdown in the fat-body, but not in muscles, negates the effects of background genetic mutants. dSir2 knockdown abrogates fat-body dFoxo-dependent lifespan extension [23246004]. Fly
    abce-1 RNAi abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    abi-1 RNAi abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    alg-1 RNAi Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Worm -9.6 to -16.1 -13.7
    alpha-Man-I RNAi alpha-Man-I RNAi knockdown results in a 39% increase in mean lifespan [19302370]. Fly +39
    aph-2 RNAi aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    apr-1 RNAi apr-1 RNAi in the adulthood extends the lifespan [99999999]. Worm
    aps-1 RNAi aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. Worm +7.9 0
    asb-1 RNAi asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. Worm +6.4 0
    B0280.9 RNAi B0280.9 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    B0393.6 RNAi B0393.6 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    bec-1 RNAi bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. Worm -14 -5
    beta-transducin RNAi beta-transducin RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    Bub1b mutation Bub1b mutation decreases median lifespan by 60% (from 15 to 6 months). Bub1b mutant mice develop many phenotypes suggestive of accelerated aging, including: progressive bilateral cataracts, substantial loss of sub dermal adipose tissue, spinal kyphosis, muscle atrophy, and decreased wound healing. Moreover, there is a pronounced increase in senescent associated Beta-galactosidase expression in late generation Bub1b mutant mice, indicative of increased rate of cellular senscence. Homozyogous knockout of Bub1b results in lethality, while heterozygous animals exhibit no aging phenotypes [15208629]. Mouse -60
    rict-1 RNAi C. elegans with mutations in the TORC2 complex gene rict-1 (Rictor) grow slowly and have small body size, and live slightly longer than wild-type when maintained on “rich” food such as the RNAi feeding strain HT115 and at elevuated temperature (25 degree Celsius) [Soukas et al., 2009 in (Robida-Stubbs et al., 2012)]. rict-1 RNAi at 20 degree Celsius in the adulthood increases mean, median, 75th %ile and maximum lifespan by 12-42, 22-29, 13-32 and 28-54%, respectively, dependent on skn-1. daf-16 is not required for lifespan to be increased by rict-1 RNAi, or when TORC1 and TORC2 are blocked by ragc-1;rict-1 RNAi. rict-1 RNAi extends mean, median, 75th %ile and maximum lifespan in the intestine-specific RNA stains VPS288 by 12-18, 19, 13-18 and 16%, respectively [22560223]. Worm +12 to +42 +22 to +42 +28 to +54
    C14A4.11 RNAi C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    C14A4.14 RNAi C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    C16C10.2 RNAi C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    C47D12.2 RNAi C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. Worm +5.5 +8.7
    C47D12.8 RNAi C47D12.8 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    C56C10.10 RNAi C56C10.10 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
    Cbs RNAi Cbs RNAi partially abrogates increased lifespan by DR, but has no effect on fully fed animals. Cbs upregulation is required for increased lifespan under low-nutrient conditions. Response of male flies to DR is muted in comparison with females [21930912]. Fly
    cchl-1 RNAi cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374]. cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374]. Worm +55 +57
    cdc-25.3 knockout cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. Worm +40
    cdk-1 RNAi cdk-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Worm
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    • 25 of 569 interventions
    Interventions are an extension of GenAge and GenDR.