• name effect species mean median maximum
    mrpl-37 RNAi Knockdown of mrpl-37 increases lifespan by 41% [23698443]. Worm +41
    mrpl-2 RNAi Knockdown of mrpl-2 increases lifespan by 54% [23698443]. Worm +54
    mrpl-1 RNAi Knockdown of mrpl-1 increases lifespan by 57% [23698443]. Worm +57
    ttl-9 RNAi Knockdown of ttl-9 throughout the entire life increases the lifespan by 3% [23698443]. Worm +3
    nkcc-1 RNAi Knockdown of nkcc-1 throughout the entire life increases the lifespan by 23% [23698443]. Worm +23
    mrps-5 RNAi Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. Worm +60
    Mlp84B RNAi RNA interference of Mlp84B specifically in the heart results in bradycardia and heart rythm abnormalities as well as a shorter mean lifespan in males but not in females [18083727]. Fly
    Ilp2 RNAi Ilp2 RNA interference results in a 24% to 47% increase in median lifespan [19005568]. Fly +24 to +47
    dys RNAi dys RNAi-mediated knockdown in the mesoderm shortens lifespan [18221418]. Fly
    CG9172 RNAi RNAi against CG9172 increases mean lifespan in females by up to 4-12% when applied in both development and adulthood, and up to 46% when applied in adult neurons only. For males the effect is variable [19747824]. Fly +4 to +46
    CG18809 RNAi RNAi of CG18809 results in a 7-19% increase in mean lifespan of females, while neural RNAi results in an increased mean lifespan of up to 12% in females. For males the results are variable [19747824]. Fly +7 to +19
    CG17856 RNAi RNAi of CG17856 results in an increase in mean lifespan of 13-18% in females. In the case of males and post-developmental experiments the results are variable [19747824]. Fly +13 to +18
    bsk RNAi RNA interference of bsk in intestinal stem cells, results in short lived mutants with impaired intestinal homeostasis and tissue regeneration. The mean lifespan of males is 16.4% lower and those of female is reduced by 10.2% [20976250]. Fly -10.2 to -16.4
    alpha-Man-I RNAi alpha-Man-I RNAi knockdown results in a 39% increase in mean lifespan [19302370]. Fly +39
    Akt1 RNAi RNA interference of Akt1 in intestinal stem cells, results in impaired regeneration of the intestinal epithelium and a short lifespan. In males and females on mean lifespan is 11.4% and 7.4% lower [20976250]. Fly -11.4 to -7.4
    Surf1 knockdown Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. Fly +20 to +30
    Sirt2 RNAi Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295]. Fly -20
    Sir2 RNAi Decreased expression of Sir2 and Sir2-like genes in all cells causes lethality during development. Suppression of the Sir2 in neurons decreases the median lifespan by 10-30%, while ubiquitous silencing of the Sir2-like genes shortens lifespan. The effects are server at 28°C that at 25°C [17159295]. Fly -10 to -30
    Sir2 knockdown A diet-dependent lifespan phenotype of dSir2 knockdown in the fat-body, but not in muscles, negates the effects of background genetic mutants. dSir2 knockdown abrogates fat-body dFoxo-dependent lifespan extension [23246004]. Fly
    frh-1 RNAi Complete absence of frataxin is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094]. Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression [23247094]. Worm +18.75 +37.037037037
    Sirt6 RNAi Decreased expression of Sirt6 by RNA interference causes lethality during development. Sirt6 silencing in neurons shortens mean lifespan by 20% [17159295]. Fly -20
    wrn-1 RNAi RNAi kockdown of wrn-1 shortens the lifespan, increases sensitivity to DNA damage, and accelerates aging phenoypes [15115755]. Worm
    lin-14 RNAi Knockdown of lin-14 only during adulthood is sufficient to extend lifespan and suppresses the short lifespan phenotype of lin-4 mutants. Worm
    alg-1 RNAi Adult-specific knockdown of the C. elegans argonaute-like gene 1 *alg-1* results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Worm -9.6 to -16.1 -13.7
    fbxa-121 RNAi RNA interference of fbxa-121 in adulthood shortens the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts [17392428]. Worm
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    • 25 of 569 interventions
    Interventions are an extension of GenAge and GenDR.