Denigma

Prx5 mutation

Species: Fruit fly
Factor: Prx5
Manipulation: Loss-of-Function, Mutation
Effect:

dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) [21826223].


References:
  • 21826223: Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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