alpha-Man-I mutation

Species: Fruit fly (Taxid: 7227)
Factor: alpha-Man-I
Manipulation: Loss-of-Function, Mutation
Effect:

alpha-Man-I mutant fly exhibit enhanced resistance to paraquat and starvation an a 60% increase in mean lifespan for both sexes. After outcrossing, the mutant exhibit, under normal conditions, an increase in mean lifespan of 22% for females and 38% for males. Maximum lifespan is increased by 15% [19302370].

Mean: +22 to +60
Maximum: +15

References:
  • 19302370: Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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