Denigma

Sirt2 RNAi

Species: Fruit fly (Taxid: 7227)
Factor: Sirt2
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

Decreased expression of Sirt2 by RNA interference causes lethality during development. Silencing in neurons shortened mean lifespan by 20% [17159295].

Mean: -20

References:
  • 17159295: Involvement of Drosophila Sir2-like genes in the regulation of life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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