Denigma

Sir2 RNAi

Species: Fruit fly (Taxid: 7227)
Factor: Sir2
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

Decreased expression of Sir2 and Sir2-like genes in all cells causes lethality during development. Suppression of the Sir2 in neurons decreases the median lifespan by 10-30%, while ubiquitous silencing of the Sir2-like genes shortens lifespan. The effects are server at 28°C that at 25°C [17159295].

Median: -10 to -30

References:
  • 17159295: Involvement of Drosophila Sir2-like genes in the regulation of life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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