Arhgap1 knockout

Species: House mouse (Taxid: 10090)
Factor: Arhgap1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Most Ahrgap1 knockout mice are weak and die during the neonatal period. Animals that survived have a shorter lifespan (median lifespan is 12 months) and show premature aging-like phenotypes, including a reduction in body mass, a loss of subdermal adipose tissue, lordokyphosis, and osteoporosis [17227869].


References:
  • 17227869: Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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