Denigma

Sir2 knockdown

Species: Fruit fly (Taxid: 7227)
Factor: Sir2
Manipulation: Loss-of-Function, Knockdown
Effect:

A diet-dependent lifespan phenotype of dSir2 knockdown in the fat-body, but not in muscles, negates the effects of background genetic mutants. dSir2 knockdown abrogates fat-body dFoxo-dependent lifespan extension [23246004].


References:
  • 23246004: dSir2 in the Adult Fat Body, but Not in Muscles, Regulates Life Span in a Diet-Dependent Manner.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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