Denigma

Metformin treatment

Species: Fruit fly (Taxid: 7227)
Factor: Met
Manipulation: Diet Intervention, Drug treatment
Effect:

In fruit fly feeding metformin to adult s results in robust AMPK activation and reduces lipid stores, but does not increase lifespan in either males or females. Administration of high concentration are even toxic [23077661].


References:
  • 23077661: Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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