mir-124 mutation

Species: Nematode (Taxid: 6239)
Factor: mir-124
Manipulation: Loss-of-Function, Mutation
Effect:

Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan [23075628].

Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants [23075628].


References:
  • 23075628: Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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