Denigma

mir-238 mutation

Species: Nematode (Taxid: 6239)
Factor: mir-238
Manipulation: Loss-of-Function, Mutation
Effect:

Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727].

Mean: -17.6 to -20
Maximum: -24

References:
  • 21129974: MicroRNAs both promote and antagonize longevity in C. elegans.
  • 22482727: The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • mir-238(n4112) vs. control ( 20°C ) : -17.6(mean) -24(max)

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