Moderate DR

Species: Budding yeast (Taxid: 4932)
Factor:
Manipulation: Dietary Restriction, Diet Intervention
Effect:

Moderate DR is the restriction of glucose concentration from 2% (ad libitum) to 0.5%, which extends the mean, median and maximum replicative lifespan by 45 - 52%, 43 - 50% and 50 - 52%, respectively [23172144]

Moderate DR increases vacuolar acidity in young cells and prevents the decline of vacuolar acidity in aging cells. DR also suppresses mitochondrial dysfunciton of aged cells (21 divisions) in a V-ATPase-dependent manner [23172144].

Constitutively activating PKA signaling by deleting the Ras GTPase-activating protein IRA2 reduces vacuolar acidity and accelerates the development of mitochondrial dysfunction in aging cells and prevents DR-mediated enhancement of vacuolar acidity and suppression of mitochondrial dysfunction [23172144].

Lifespan extension by DR is prevented in a strain lacking V-ATPase activity [23172144].

Mean: +45.2 to +51.7
Median: +42.9 to +50.0
Maximum: +50.0 to +52.0

References:

23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.

Comparisons:

WT DR vs. WT : 45.2(mean) 42.9(median) 50(max) <0.0001(p-value)

WT DR vs. WT : 51.7(mean) 50(median) 52(max) <0.0001(p-value)

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