Denigma

ZDS1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: ZDS1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of ZDS1 increases replicative lifespan by 37% in a SIR3-dependent manner [10662670].

Null mutation in ZDS1 causes 100-fold decrease in telomeric silencing, a nine-fold increase in rDNA silencing, reduces rDNA recombination, and decreases Sir3 phosphorylation [10662670].

Mean: +37

References:
  • 10662670: Two paralogs involved in transcriptional silencing that antagonistically control yeast life span.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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