Symbol: Prx5
Name: Peroxiredoxin 5
Entrez gene ID: 3771951
Ensembl gene ID: FBgn0038570
Species: Fly
(Taxid: 7227)
Observation:
Prx5 overexpression causes an increase in mean and median lifespan under normal conditions. It also leads to a small increase in maximum lifespan.
dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) [21826223].
Interventions:
Prx5 overexpression
Prx5 mutation
Assays:
Organismal Lifespan
Classification:
Aging-Suppressor
Negative Aging-Suppressor
Positive Aging-Suppressor
Type:
Gene
Protein coding
References:
21826223: Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.
Aging Relevance Analysis/Source:
GenAge
GenDR
Homologs
PRDX5
(9606)
PRDX5
(9598)
PRDX5
(9615)
PRDX5
(9913)
Prdx5
(10090)
Prdx5
(10116)
prdx5
(7955)
Prx5
(7227)
AgaP_AGAP001325
(7165)
SPCC330.06c
(4896)
KLLA0A07271g
(28985)
AGOS_ADL154C
(33169)
GeneID:2674787
(148305)
NCU06880
(5141)
AT3G52960
(3702)
Os02g0192700
(4530)
Os06g0625500
(4530)
Inparanoids
ENSMUSP00000025904 (10090)
ENSRNOP00000039908 (10116)
ENSMMUP00000017596 (9544)
ENSP00000265462 (9606)
YLR109W (4932)
SPCC330.06c (4896)
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