Prx5

Symbol: Prx5
Name: Peroxiredoxin 5
Entrez gene ID: 3771951
Ensembl gene ID: FBgn0038570
Species: Fly (Taxid: 7227)


Observation:

Prx5 overexpression causes an increase in mean and median lifespan under normal conditions. It also leads to a small increase in maximum lifespan.

dprx5(-/-) null mutants are comparatively more susceptible to oxidative stress, have higher incidence of apoptosis, and a shortened mean lifespan, but thee is no significant difference in maximum lifespan (10% survival) [21826223].



Interventions:
  • Prx5 overexpression
  • Prx5 mutation

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • Type:
  • Gene
  • Protein coding

    References:
  • 21826223: Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PRDX5 (9606)
  • PRDX5 (9598)
  • PRDX5 (9615)
  • PRDX5 (9913)
  • Prdx5 (10090)
  • Prdx5 (10116)
  • prdx5 (7955)
  • Prx5 (7227)
  • AgaP_AGAP001325 (7165)
  • SPCC330.06c (4896)
  • KLLA0A07271g (28985)
  • AGOS_ADL154C (33169)
  • GeneID:2674787 (148305)
  • NCU06880 (5141)
  • AT3G52960 (3702)
  • Os02g0192700 (4530)
  • Os06g0625500 (4530)

  • Inparanoids
  • ENSMUSP00000025904 (10090)
  • ENSRNOP00000039908 (10116)
  • ENSMMUP00000017596 (9544)
  • ENSP00000265462 (9606)
  • YLR109W (4932)
  • SPCC330.06c (4896)



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