Denigma

MTF-1

Symbol: MTF-1
Name: Metal response element-binding Transcription Factor-1
Entrez gene ID: 39089
Ensembl gene ID: FBgn0040305
Species: Fly (Taxid: 7227)


Observation:

MTF-1 overexpression in either the peripheral nervous system or motorneurons extends both mean and maximum lifespan by 40% in males [18775584].



Interventions:
  • MTF-1 overexpression +40% +40%

    • Assays: Organismal Lifespan
    Mean: +40
    Maximum: +40

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


    • Type:
  • Gene
  • Protein coding

    References:
  • 18775584: Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • MTF-1 (7227)
  • AgaP_AGAP007377 (7165)

    • Inparanoids
  • ENSRNOP00000006287 (10116)



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