TOMM40

Symbol: TOMM40
Name: translocase of outer mitochondrial membrane 40 homolog (yeast)
Alias: APOE; APOC1
Entrez gene ID: 10452
Ensembl gene ID: ENSG00000130204
Species: Human (Taxid: 9606)

Function:
Mitochondrial function; Channel-forming unit of mitochondrial outer membrane translocase

Observation:

TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].

rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2075650 2.65e-06 [21418511]
  • rs2075650 0.002 [23040522]
  • rs2075650 2.36e-10 [22279548]
  • rs10119 0.914 [24924924]
  • rs2075650 0.006 [24924924]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 22279548: Genetic signatures of exceptional longevity in humans.
  • 23286790: Genome-wide linkage analysis for human longevity: Genetics of Healthy Ageing Study.
  • 21418511: Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.
  • 23040522: Apolipoprotein E and familial longevity.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • TOMM40 (9606)
  • TOMM40 (9615)
  • TOMM40 (9913)
  • Tomm40 (10090)
  • Tomm40 (10116)
  • tomm40l (7955)
  • tomm40 (7955)
  • Tom40 (7227)
  • tomboy40 (7227)
  • AgaP_AGAP007871 (7165)
  • C18E9.6 (6239)
  • tom40 (4896)
  • TOM40 (4932)
  • KLLA0F06292g (28985)
  • AGOS_AFL183C (33169)
  • GeneID:2678871 (148305)
  • NCU01179 (5141)
  • AT1G50400 (3702)

  • Inparanoids
  • ENSP00000252487 (9606)
  • ENSMUSP00000104090 (10090)
  • ENSRNOP00000025281 (10116)
  • ENSMMUP00000018785 (9544)
  • YMR203W (4932)
  • SPBC27B12.13 (4896)
  • ENSP00000252487 (9606)



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