The Ras and Sch9 pathways regulate stress resistance and longevity.

Authors: Longo, Valter D

Abstract: Depending on the availability of extracellular nutrients, yeast can enter either high or low metabolism survival phases. We have identified two pathways that regulate longevity and stress resistance in both the low and high metabolism phases. The deletion of SCH9, which encodes for a serine threonine kinase, triples the mean life span and increases resistance to oxidative and thermal stress. Mutations that decrease the activity of the Ras/Cyr1/PKA pathway also extend longevity and increase stress resistance by activating transcription factors Msn2/Msn4 and the mitochondrial antioxidant enzyme superoxide dismutase (Sod2). Although only one intracellular pathway that includes genes homologous to SCH9 and SOD2 has been identified in worms, our studies in yeast suggest that longevity in higher eukaryotes may also be negatively regulated by the Ras pathway.

Keywords: DNA-Binding Proteins/metabolism; Gene Deletion; *Genes, ras; Longevity/genetics; Oxidation-Reduction; Protein Kinases/genetics/*metabolism; *Saccharomyces cerevisiae Proteins; Signal Transduction/*physiology; Superoxide Dismutase/metabolism; Transcription Factors/metabolism; Yeasts/*physiology
Journal: Exp Gerontol
Volume: 38
Issue: 7
Pages: 807-11
Date: July 12, 2003
PMID: 12855292
Select reference article to upload


Citation:

Longo, Valter D (2003) The Ras and Sch9 pathways regulate stress resistance and longevity. Exp Gerontol 38: 807-11.


Study
Update (Admin) | Auto-Update

Comment on This Data Unit