Authors: van Rossum EF; Feelders RA; van den Beld AW; Uitterlinden AG; Janssen JA; Ester W; Brinkmann AO; Grobbee DE; de Jong FH; Pols HA; Koper JW; Lamberts SW
Abstract: PURPOSE: We recently demonstrated that a polymorphism in codons 22 and 23 of the glucocorticoid receptor gene is associated with relative glucocorticoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels. In the present study, we investigated whether the ER22/23EK polymorphism is associated with survival, cholesterol levels, and two predictors of mortality: serum C-reactive protein and interleukin 6 levels. METHODS: We studied 402 men (mean [+/- SD] age, 77.8 +/- 3.6 years). C-reactive protein was measured by a highly sensitive method using a latex-enhanced immunoephelometric assay. Interleukin 6 was determined by a commercially available immulite assay. RESULTS: After a follow-up of 4 years, 73 (19%) of 381 noncarriers died, while none of the 21 ER22/23EK carriers had died (P = 0.03). C-reactive protein levels were about 50% lower in ER22/23EK carriers (P = 0.01). There were no differences in interleukin 6 levels. CONCLUSION: Carriers of the ER22/23EK polymorphism have better survival than noncarriers, as well as lower C-reactive protein levels.
Keywords: Aged; C-Reactive Protein/*analysis; Codon; Follow-Up Studies; Heterozygote; Humans; Interleukin-6/blood; *Longevity; Male; *Polymorphism, Genetic; Receptors, Glucocorticoid/*genetics|
Journal: The American journal of medicine Volume: 117 Issue: 3 Pages: 158-62 Date: July 28, 2004 PMID: 15276593 |
van Rossum EF, Feelders RA, van den Beld AW, Uitterlinden AG, Janssen JA, Ester W, Brinkmann AO, Grobbee DE, de Jong FH, Pols HA, Koper JW, Lamberts SW (2004) Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. The American journal of medicine 117: 158-62.
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