A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans.

Authors: Ishii N; Takahashi K; Tomita S; Keino T; Honda S; Yoshino K; Suzuki K

Abstract: A methyl viologen (paraquat)-sensitive mutant, mev-1 (LG III), in Caenorhabditis elegans was about 4 times more sensitive to methyl viologen than the wild type. This mutant was also hypersensitive to oxygen. The brood size was about 1/4 that of the wild type. The average life span was determined to be 9.3 days as compared to 14.3 days for the wild type. The activity of superoxide dismutase (SOD), a scavenging enzyme for superoxide anion, was about half the wild-type level. We suggest that oxygen radicals may be involved in the normal aging mechanism in C. elegans.

Keywords: Animals; Caenorhabditis/drug effects/*genetics/physiology; *Mutation; Oxygen/pharmacology; Paraquat/*pharmacology; Superoxide Dismutase/metabolism
Journal: Mutation research
Volume: 237
Issue: 3-4
Pages: 165-71
Date: May 1, 1990
PMID: 2233820
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Citation:

Ishii N, Takahashi K, Tomita S, Keino T, Honda S, Yoshino K, Suzuki K (1990) A methyl viologen-sensitive mutant of the nematode Caenorhabditis elegans. Mutation research 237: 165-71.



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