Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

Authors: Shepherd JC; Walldorf U; Hug P; Gehring WJ

Abstract: In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

Keywords: Animals; Drosophila melanogaster/*genetics/physiology; Eukaryotic Initiation Factor-1/*genetics; Longevity; Male; Mutation; Plasmids; RNA, Messenger/genetics; Transcription, Genetic
Journal: Proceedings of the National Academy of Sciences of the United States of America
Volume: 86
Issue: 19
Pages: 7520-1
Date: Oct. 1, 1989
PMID: 2508089
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Citation:

Shepherd JC, Walldorf U, Hug P, Gehring WJ (1989) Fruit flies with additional expression of the elongation factor EF-1 alpha live longer. Proceedings of the National Academy of Sciences of the United States of America 86: 7520-1.


Study Lifespan Factors:
  • Ef1alpha48D Elongation factor 1alpha48D


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