Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster.

Authors: Orr WC; Sohal RS

Abstract: The hypothesis that oxygen free radicals are causally involved in the aging process was tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide dismutase and catalase. As compared to diploid controls, transgenic flies carrying three copies of each of these genes exhibited as much as a one-third extension of life-span, a longer mortality rate doubling time, a lower amount of protein oxidative damage, and a delayed loss in physical performance. Results provide direct support for the free radical hypothesis of aging.

Keywords: Aging/genetics/*physiology; Animals; Animals, Genetically Modified; Catalase/genetics/*metabolism; Drosophila melanogaster/enzymology/genetics/*physiology; Female; Gene Expression; Longevity; Male; Oxidation-Reduction; Oxygen Consumption; Proteins/metabolism; Reactive Oxygen Species/metabolism; Superoxide Dismutase/genetics/*metabolism

Journal: Science (New York, N.Y.) Volume: 263 Issue: 5150 Pages: 1128-30 Date: Feb. 25, 1994 PMID: 8108730

Select reference article to upload leave this field blank to prove your humanity

Citation:

Orr WC, Sohal RS (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science (New York, N.Y.) 263: 1128-30.

Study Lifespan Factors:

Cat Catalase

Sod1 Superoxide dismutase

---

---

Back to top

---