Authors: Berger B; Peng J; Singh M
Abstract: High-throughput experimental technologies are generating increasingly massive and complex genomic data sets. The sheer enormity and heterogeneity of these data threaten to make the arising problems computationally infeasible. Fortunately, powerful algorithmic techniques lead to software that can answer important biomedical questions in practice. In this Review, we sample the algorithmic landscape, focusing on state-of-the-art techniques, the understanding of which will aid the bench biologist in analysing omics data. We spotlight specific examples that have facilitated and enriched analyses of sequence, transcriptomic and network data sets.
Keywords: Algorithms; Computational Biology/*methods; Data Mining; Databases, Genetic; Gene Expression Profiling; Genomics/*methods; High-Throughput Nucleotide Sequencing/methods; Humans; Sequence Analysis, DNA/methods; Software|
Journal: Nature reviews. Genetics Volume: 14 Issue: 5 Pages: 333-46 Date: April 19, 2013 PMID: 23594911 |
Berger B, Peng J, Singh M (2013) Computational solutions for omics data. Nature reviews. Genetics 14: 333-46.
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