Authors: Laplana M; Fibla J
Abstract: Although persistent inflammation has been related to unsuccessful aging, a pro-inflammatory status is the common phenotype in older people. To assess for a genetic component in the inflammatory status of the oldest we studied the distribution of two polymorphic chemokine pathway genes, RANTES and CCR5, in elderly. RANTES -403G/A and RANTES Int1.1T/C polymorphisms and CCR5Delta32 polymorphism were genotyped in 104 elderly and 110 controls. RANTES -403A and RANTES Int1.1C alleles have been associated with pro-inflammatory and anti-inflammatory status, respectively. CCR5Delta32 abrogates functional receptor expression of the pro-inflammatory CCR5-mediated action. Prevalence of RANTES -403G allele, associated in other studies with high RANTES production, was reduced in elderly males, compared with controls. In addition, RANTES pro-inflammatory haplotype -403A-Int1.1T was overrepresented in elderly males, while RANTES anti-inflammatory haplotype -403G-Int1.1C was overrepresented in elderly females. Our results suggest a sex-specific RANTES inflammatory genetic determinant that could contribute to the known sex-related differences in aging.
Keywords: Adolescent; Adult; Aged, 80 and over; Chemokine CCL5/*genetics; Female; Humans; Inflammation/genetics; Longevity/*genetics; Male; Polymorphism, Genetic; Receptors, CCR5/*genetics|
Journal: Cytokine Volume: 58 Issue: 1 Pages: 10-3 Date: Jan. 24, 2012 PMID: 22265023 |
Laplana M, Fibla J (2012) Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals. Cytokine 58: 10-3.
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