Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.

Authors: Cai XY; Wang XF; Li SL; Qian J; Qian DG; Chen F; Yang YJ; Yuan ZY; Xu J; Bai Y; Yu SZ; Jin L

Abstract: BACKGROUND: Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. METHODOLOGY/PRINCIPAL FINDINGS: To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao--a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged > or = 95 yr (EL group). Control subjects include 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). CONCLUSIONS: Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.

Keywords: Aged; China; DNA, Mitochondrial/*genetics; Female; *Haplotypes; Humans; *Longevity; Male; Middle Aged; Polymorphism, Single Nucleotide
Journal: PloS one
Volume: 4
Issue: 7
Pages: e6423
Date: July 31, 2009
PMID: 19641616
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Citation:

Cai XY, Wang XF, Li SL, Qian J, Qian DG, Chen F, Yang YJ, Yuan ZY, Xu J, Bai Y, Yu SZ, Jin L (2009) Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population. PloS one 4: e6423.


Longevity Variant Associations (p-value):
  • 10400T
  • 5178A,10400T (0.387)
  • 3010A,5178A,10400T (0.141)
  • 14979C,3010A,5178A,10400T (0.781)
  • 8020A,3010A,5178A,10400T (0.549)
  • 8964T,8020A,3010A,5178A,10400T (0.319)
  • 9296T,8964T,8020A,3010A,5178A,10400T (0.55)
  • 1107C,5178A,10400T (0.559)
  • 14569A,10400T (0.796)
  • 4833G,14569A,10400T (0.949)
  • 7600A,4833G,14569A,10400T (0.153)
  • 9824C,10400T (0.955)
  • 12811C,9824C,10400T (0.587)
  • 7196A,10400T (0.847)
  • 8684T,7196A,10400T (0.457)
  • 13263G,7196A,10400T (0.485)
  • 4491A,3705G,10400T (0.027)
  • 10646A,10400T (0.753)
  • 10873T
  • 5417A,10873T (0.018)
  • 12358G,5417A,10873T (0.058)
  • 1736G,10873T (0.288)
  • 3970T,12705C,10873T (0.147)
  • 12406A,3970T,12705C,10873T (0.304)
  • 9bp-deletion,10873T (0.311)
  • 8584A,9bp-deletion,10873T (0.117)
  • 15235G,8584A,9bp-deletion,10873T (0.086)
  • 15662G,8584A,9bp-deletion,10873T (0.357)
  • 5465C,9bp-deletion,10873T (0.105)
  • 13590A,9bp-deletion,10873T (0.43)

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