Authors: Nygaard M; Soerensen M; Flachsbart F; Mengel-From J; Tan Q; Schreiber S; Nebel A; Christensen K; Christiansen L
Abstract: In addition to APOE and FOXO3, AKT1 has recently been suggested as a third consistent longevity gene, with variants in AKT1 found to be associated with human lifespan in two previous studies. Here, we evaluated AKT1 as a longevity-associated gene across populations by attempting to replicate the previously identified variant rs3803304 as well as by analyzing six additional AKT1 single-nucleotide polymorphisms, thus capturing more of the common variation in the gene. The study population was 2996 long-lived individuals (nonagenarians and centenarians) and 1840 younger controls of Danish and German ancestry. None of the seven SNPs tested were significantly associated with longevity in either a case-control or a longitudinal setting, although a supportive nominal indication of a disadvantageous effect of rs3803304 was found in a restricted group of Danish centenarian men. Overall, our results do not support AKT1 as a universal longevity-associated gene.
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Journal: European journal of human genetics : EJHG Volume: 21 Issue: 5 Pages: 574-7 Date: Aug. 30, 2012 PMID: 22929028 |
Nygaard M, Soerensen M, Flachsbart F, Mengel-From J, Tan Q, Schreiber S, Nebel A, Christensen K, Christiansen L (2013) AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians. European journal of human genetics : EJHG 21: 574-7.
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