Authors: Roszkowska-Gancarz M; Kurylowicz A; Polosak J; Ambroziak M; Puzianowska-Kuznicka M
Abstract: BACKGROUND: Women live longer than men. Some possible reasons for this advantage are the protection provided by high concentrations of 17beta-estradiol (E2) during the premenopausal period and polymorphic variants of the estrogen receptors (ERs), which mediate various cardiovascular functions of E2. METHODS: We tested whether the -351A/G and -397T/C polymorphisms of the ERalpha-encoding ESR1 were associated with extreme longevity. The genomic DNA of 148 centenarians (C), 414 young controls (Y), and 208 myocardial infarction patients (MI) was analyzed by RFLP-PCR. RESULTS: Both polymorphisms were equally distributed in the Y, C, and in centenarians never diagnosed with MI (HC). In centenarians, none of these polymorphisms was associated with a particular lipid profile. The AA genotype of the -351A/G polymorphism was less frequent in the C, HC and Y groups than in MI patients (p=0.058, p=0.021, and p=0.004, respectively). In MI patients, the GG genotype of the -351A/G polymorphism was associated with significantly lower mean total cholesterol, LDL, and HDL levels compared to the AG (p=0.0194, p=0.0213, and p=0.0367, respectively) and AA genotypes (p=0.0014, p=0.0078, and p=0.0448, respectively). CONCLUSIONS: The -351A/G ESR1 polymorphism might be associated with MI, but not with extreme longevity.
Keywords: Adolescent; Adult; Aged, 80 and over; Case-Control Studies; Estrogen Receptor alpha/*genetics; Female; *Genetic Predisposition to Disease; Humans; Longevity/*genetics; Male; Middle Aged; Myocardial Infarction/*genetics/metabolism; *Polymorphism, Single Nucleotide; Young Adult|
Journal: Clinica chimica acta; international journal of clinical chemistry Volume: 411 Issue: 23-24 Pages: 1883-7 Date: July 6, 2010 PMID: 20599431 |
Roszkowska-Gancarz M, Kurylowicz A, Polosak J, Ambroziak M, Puzianowska-Kuznicka M (2010) The -351A/G polymorphism of ESR1 is associated with risk of myocardial infarction but not with extreme longevity. Clinica chimica acta; international journal of clinical chemistry 411: 1883-7.
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