Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP.

Authors: Lio D; Scola L; Crivello A; Colonna-Romano G; Candore G; Bonafé M; Cavallone L; Marchegiani F; Olivieri F; Franceschi C; Caruso C

Keywords: Adult; Age Factors; Aged; Aged, 80 and over; DNA/chemistry/genetics; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Inflammation/*genetics; Interleukin-10/*genetics; Longevity/*genetics; Male; Middle Aged; Polymorphism, Single Nucleotide/*genetics; Promoter Regions, Genetic/*genetics; Tumor Necrosis Factor-alpha/*genetics
Journal: Journal of medical genetics
Volume: 40
Issue: 4
Pages: 296-9
Date: April 5, 2003
PMID: 12676903
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Citation:

Lio D, Scola L, Crivello A, Colonna-Romano G, Candore G, Bonafé M, Cavallone L, Marchegiani F, Olivieri F, Franceschi C, Caruso C (2003) Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP. Journal of medical genetics 40: 296-9.


Longevity Variant Associations (p-value):
  • rs1800896 (0.019)
  • rs1800629 (1.0)
  • rs1800896 - rs1800629 (0.038)

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