Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles

Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10556-60. doi: 10.1002/anie.201204663. Epub 2012 Sep 20.

Abstract

Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated β-galactosidase (SA-β-gal), and releases the cargo upon entry into SA-β-gal expressing cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cellular Senescence
  • Drug Delivery Systems / instrumentation
  • Drug Delivery Systems / methods*
  • Fluorescent Dyes / administration & dosage
  • Fluorescent Dyes / chemistry
  • Humans
  • Nanoparticles / chemistry*
  • Porosity
  • Rhodamines / administration & dosage
  • Rhodamines / chemistry
  • Silicon Dioxide / chemistry*
  • beta-Galactosidase / chemistry
  • beta-Galactosidase / metabolism

Substances

  • Fluorescent Dyes
  • Rhodamines
  • Silicon Dioxide
  • beta-Galactosidase
  • rhodamine B