Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

Authors: Lio D; Candore G; Crivello A; Scola L; Colonna-Romano G; Cavallone L; Hoffmann E; Caruso M; Licastro F; Caldarera CM; Branzi A; Franceschi C; Caruso C

Keywords: Adult; Aged; Aged, 80 and over; Aging/*genetics/*physiology; Alleles; Base Sequence; Cardiovascular Diseases/*genetics/immunology; Haplotypes/genetics; Humans; Interleukin-10/*genetics/immunology; Italy; Longevity/*genetics; Male; Middle Aged; Myocardial Infarction/genetics/immunology; Polymorphism, Genetic/*genetics
Journal: Journal of medical genetics
Volume: 41
Issue: 10
Pages: 790-4
Date: Oct. 7, 2004
PMID: 15466015
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Citation:

Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, Hoffmann E, Caruso M, Licastro F, Caldarera CM, Branzi A, Franceschi C, Caruso C (2004) Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. Journal of medical genetics 41: 790-4.


Longevity Variant Associations (p-value):
  • rs1800896 (0.0003)
  • --1082G-->A (0.0001)
  • rs1800896 (0.0003)

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