Authors: Taioli E; Mari D; Franceschi C; Bonafè M; Monti D; Bertolini S; Marinelli D; Garte S
Abstract: Drug metabolizing enzymes are involved in the detoxification of several drugs, environmental substances, and carcinogenic compounds, and their polymorphisms have been associated with risk for a variety of cancer. In this paper, we compared the frequency of polymorphisms in cytochrome P450-1A1 gene (CYP1A1), a phase 1 gene (oxidation, activation), and of two polymorphisms of glutathione S-transferase enzymes (GSTM1, GSTT1), two phase 2 genes (conjugation, detoxification). Two groups were studied and compared, i.e., 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for a GSTT1 deletion (28%) was observed in comparison to control subjects (19%, P = 0.03). The distribution of the other gene polymorphisms did not differ in the two groups. These findings on phase 2 drug-metabolizing enzyme gene polymorphisms may help in disentangling gene-environmental interactions which can have a role in successful aging and longevity, as well as in cancer incidence in the oldest old.
Keywords: Adolescent; Adult; Aged; Aged, 80 and over; *Aging; Child; Child, Preschool; Cytochrome P-450 CYP1A1/*genetics/metabolism; Female; Gene Frequency; Genotype; Glutathione Transferase/*genetics/metabolism; Heterozygote; Homozygote; Humans; Male; Middle Aged; *Polymorphism, Genetic|
Journal: Biochemical and biophysical research communications Volume: 280 Issue: 5 Pages: 1389-92 Date: Feb. 13, 2001 PMID: 11162685 |
Taioli E, Mari D, Franceschi C, Bonafè M, Monti D, Bertolini S, Marinelli D, Garte S (2001) Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: difference at GSTT1 locus. Biochemical and biophysical research communications 280: 1389-92.
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