Authors: Bruckbauer, Antje; Zemel, Michael B
Abstract: Oxidative and inflammatory stress have been implicated as major contributors to the aging process. Dietary Ca reduced both factors in short-term interventions, while milk exerted a greater effect than supplemental Ca. In this work, we examined the effects of life-long supplemental and dairy calcium on lifespan and life-span related biomarkers in aP2-agouti transgenic (model of diet-induced obesity) and wild-type mice fed obesigenic diets until their death. These data demonstrate that dairy Ca exerts sustained effects resulting in attenuated adiposity, protection against age-related muscle loss and reduction of oxidative and inflammatory stress in both mouse strains. Although these effects did not alter maximum lifespan, they did suppress early mortality in wild-type mice, but not in aP2-agouti transgenic mice.
Keywords: Adiposity/drug effects; Agouti Signaling Protein/metabolism; Animals; Biological Markers/metabolism; Calcium, Dietary/*pharmacology; Case-Control Studies; *Dairy Products; Diet; Disease Models, Animal; Fatty Acid-Binding Proteins/metabolism; Humans; Inflammation/metabolism; Life Expectancy; Male; Mice; Mice, Transgenic; Obesity/*metabolism; Oxidative Stress/*drug effects|
Journal: Nutrients Volume: 1 Issue: 1 Pages: 50-70 Date: Jan. 1, 2009 PMID: 22253967 |
Bruckbauer, Antje, Zemel, Michael B (2009) Dietary calcium and dairy modulation of oxidative stress and mortality in aP2-agouti and wild-type mice. Nutrients 1: 50-70.
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