Denigma

Datasets

Changes

Denigma cartographies changes from the molecular level to whole physiology which occur in defined contrasts such as aging and dietary as well as genetic lifespan-extending interventions:

  • aging (young vs. old)
  • dietary (DR vs. AL)
  • genetic (mutant vs. wild-type) o
ID name taxid reference pmid tissue comparision start stop gender description
47 Melatonin declines 9606 — — — Age 70/35 year — male/female Melatonin peaks at night and peaks keeps dropping throughout your life and can drop by 60% by the time an individual reaches age 50. Increased age is associated with a reduction in noctronal melatonin vlaues. This drop correlates with reduction in the TAS of the blood (From Benot et al (123)).
48 Growth hormone declines 9606 — — — Age 70/35 year — male/female —
49 Progesterone declines 9606 — — — Age 70/35 year — male/female —
50 Vitamin D3 declines 9606 — — — — — — — As one gets odler te ability for one's skin to create Vitamin D3 declines dramatically.
58 Hippocampal atrophy 9606 — — Hippocampus age 56 84 males/females Shrinkage of hippocampus occurs with age. Several genes and genomic loci are associated with this process, among them are genes implicated in cell death (HRK), embryonic development (WIF1), diabetes (DPP) and neuronal migration (ASTN2) [22504421;22504417].
60 Protein aggregation 6239 — 22103665 whole body age 1 day 11 day hermaphrodites protein aggreation accumulate in aged animals. Hundrets of protein are enriched in an SDS-insoluble fraction in aged nematode adn alre largely absent from similiar protein fraction in young nematodes. Genes encoding proteins that become insoluble with age are enriched for modifiers of lifespan [22103665].
61 Loss of protein homeostasis 6239 — 22103665 whole body — 1 day 11 day hermaphrodites Loss in protein homeostasis during aging may lead to impaird protein solubility and cellular dysfunction [22103665].
62 Fertility declines 6239 — 20041217 whole body age — — females Fertility and reproduction sharply decline in early/mide-adulthood, folloed by a long post-reproductuve period, followed by a long-post-reproductive period [6,7 in 20041217].
67 Bone loss 10090 — 13678781 bone age 42 week 104 week male In young mice the rapid growth is marked by substantial increase in bone size, mineral mass and mechanical properties. Maturation occurring between 12 and 42 weeks of age was characterized with the maintenance of bone mass and mechanical properties. From the peak levels, mice aged for 104 weeks exhibited decreased whole femur mass, percentage of mineralization diminished whole bone stiffness, energy to fracture and decreased cortical thickness. Periosteal perimeter and, consequently the cross-sectional moments of inertia continued to increase through 104 weeks, compensating for cortical thinning and increased brittleness due to decreased mineralization and stiffness. The shape of the mid-diaphysis became increasingly less elliptical in aged mice. After 52 weeks excessive endocortical resorption appeared, indicating a shift in normal mechanisms regulating bone shape and locating, suggestive of remodelling [13678781].
68 Increase in upper and central body fat deposition 9606 — 2921472 — age — — — There are progressive trends toward increasing upper and central body fat deposition with age with a postmenopausal acceleration of these trends in women [2921472].
69 Loss of subcutaneous adipose skin layer 10090 — 19013273 skin age 5 165 — With increasing age the subcutaneous adipose layer becomes thinner (5-12 weeks vs. 123-165 weeks) and this loss is associated with increased risk of skin injuries and infections [19013273].
70 IGF1 levels decline 9606 — 3322823 plasma age — — — A decline in IGF1 expression occurs with age progression. Levels of circulating IGF1 in humans are low at birth, rise progressively during childhood and peak during midadolescence, and then progressively fall as a function of age. Reduction in levels of circulating IGR1 is related to decreased secretion of growth hormone [3322823].
71 Telomere shortening 10090 — 22585399 — age — — — Average telomere length decreases with age concomitant with an increase in short telomeres [22585399]. Mouse telomeres suffer a dramatic shortening at old ages [18283121;16582880].
72 IGF2 level changes 9606 — 3322823 plasma age — — — Circulating IGF2 reaches “adult” levels early in childhood, and changes are relatively small as a function of increasing age [3322823].
73 p16 expression increases 10090 — — — age — — — p16 levels increase with aging in many tissues [16957737;16957738] and is a marker of cellular senescence.
74 Reduced regenerative capacity — — — — — — — — Aging in mammals is associated with reduced regenerative capacity in tissues that contain stem cells [15734685;11919569].
75 Metabolic and mitochondrial decline 10090 — 22585399 — age — — males/females 2 years old mice exhibit metabolic and mitochondrial decline [22585399].
78 Sir2 decline 4932 — 21436897 — age — — — Sir2 levels exhibit an age-related decline at an age of about one thir lifespan expectancies [21436897].
79 Vacuolar membrane deteriorates 4932 — 18690010 — age — — — The vacuolar membrane deteriorates as judged by Vac8 localisation at or before generations 6-7. At generation 6-7, cells begin to exhibit large round vacoules and vacoules with invaginated vacoular membranes [18690010].
80 Cisd2 expression declines — — 22661501 — age — — — Cisd2 expression decreases with age [22661501].
82 elt-6 expression increases 6239 — 17608836 — age — — — Expression of elt-6 increases during devleopment and aging [17608836].
83 elt-3 expression increases 6239 — 17608836 — age — — — Expression of elt-3 increases during devleopment and aging [17608836].
85 Cell proliferation decreases 10116 — 11744049 — Diet — — — 24 month DR in rats inhibits cell proliferation in glandular stomach and liver tissue [11744049].
87 LysoPC(16:1) decrease 10090 — 22661299 — — 3 months 12 momths — Plasma levels of LysoPC(16:1) decreases with age from 3 to 22 months [22661299].
88 Structural chromosome variation 9606 — — — — — — — Acquired differences in structural chromosome variants between members of monozygoutic twin pairs (including mosaic anomalis) are observed in pairs of >55 years of age but not in younger [29 in Laurie et al. 2012].
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  • 25 of 129 Biological changes

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