Created on Dec. 24, 2012, 10:17 p.m. by Hevok & updated by Hevok on May 2, 2013, 4:57 p.m.

Exercise is any bodily activity that enhances or maintains physical fitness and overall health/well-being. Give mice a running while, and they will run from 3 to 7 miles every night. It seems to let their brains retain their ability to generate nerve cells. Steady exercise reduces blood levels of various pro-inflammatory molecules whose concentrations typically rise as we age [http://stanmed.stanford.edu/2011fall/article9.html].

Exercise is the safest and much more socially acceptable way to delay Aging, compared to Dietary Restriction. Just like Dietary Restriction, Exercise has at least 10 overlapping mechanisms of action:

  1. AMPK activation
  2. mTOR inhibition
  3. PGC-1a activation
  4. Autohagy activation
  5. Proteasome activation
  6. FOXO3a translocation to nucleus
  7. Lowering mitochondrial baseline ROS
  8. ROS-mediated Nrf2 translation to the nucleus and turning on ARE genes
  9. hypoxia induced HIF-1 translocation to the nucleus, and turning on the latitude response elements
  10. SIRT1,2,3 and 4 mediated deacetylation of multiple proteins
  11. reduced epigenetic drift
  12. DNA repair activation
  13. Klotho pathway activation
  14. Surprising counter-intuitive effect on hGH and downstream IGF-1 (increased, not decreased)

These benefits far outweigh the negative effects of NF-kB activation, norepinephrine output from the adrenal gland, glucocorticoid output from the adrenal gland


Tags: sport, aging, health, intervention
Categories: News
Parent: Aging

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