Created on Dec. 21, 2012, 6:29 p.m. by Hevok & updated by Hevok on May 2, 2013, 4:54 p.m.

T-Cells (T-lymphocytes) are white blood cells which are central components of the cell-mediated immunity. The characteristic features is the presence of a T-Cell receptor (TCR) on the plasma membrane. T-Cells mature in the Thymus. Several subsets of T-Cells exist, each one with a specific function.

T-Cells undergo defined age-related changes:

  • decrease in CD4/8 ratio
  • increase in the number of memory-like T-cells (CD44+), especially in CD8+44+
  • decrease in proliferative capacity during TCR stimulation
  • decrease in the production of naive T-cells

Tags: immunology, aging, senescence, immune system
Categories: News
Parent: Immune System

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