Temperature

In some cold-blooded species endocrine changes accompany differences in temperature which could have an impact on gene expression and on specific signalling pathways.

C. elegans survials experiments are most often conducted at 20 or 22.5, or 24 degree celsius, but also at other temperatures including 16, 22.5, 24 degree Celsius.

In contrast gene expression studies have mostly been conducted at 25 or 25.5 degree Celsius in order to reder ts fertility mutant infertile and therefore reducing or preventing progeny but also to speed up aging.

Poikiloherms are effected by ambient temperature, but not nearly as much as would be expected from typical Q10's of chemical reactions because of compensating mechanisms which must be introduced rather early in evolution.

20 degree celsius is the highest temperature at which ts mutants in IIS genes like daf-2 can be grown up.

Temperature and the rate of ageing in Drosophila subobscura

Stabiliyation of HIF-1 increases lifespan robustly under all conditions. Deletion of hif-1 increases lifespan in a temperature-dependent manner


Tags: cold

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