Virtually all physiological function of tissues or organs decline with increasing age. Ageing-differentially expressed genes exhibit a clear tissue-specific pattern. < 10% of them in each tissue were in common with any other tissue and < 10% of biological processes were in common with any other tissue [17623811].

Critical changes of the transcriptional levels generally occurs after 30 days of age, some as late as 60 days, indicating that aging gene expression changes are a gradual process [17623811].

SdhB, ATP synthase, ferritin and aconitase in nematode [Hamilton et al. 2005; Hansen et al. 2005] and Indy and SdhB in fruit fly [Rogina et al. 200; Walker et al. 2006] modulate lifespan.

Reducing expression of IIS genes such as daf-2 in the adult stage alone lifespan [Dillin et al. 2002].

Genome-wide transcriptional studies on aging in invertebrates [Zou et al. 2000; Lund et al. 2002; Pletcher et al. 2002; Landis et al. 2004; Wang et al. 2004; Kim et al. 2005; Girardot et al. 2006; Golden & Melov, 2004; McCarroll].

Comparison of aging profiles among different tissues [Fraser et al. 2005; Zhan et al. 2006].

Comparison of aging profiles among different species found alterations in transcripts encoding mitochondrial and proteasomal functions [McCarroll et al. 2004].

References

Hamilton, B., Dong, Y., Shindo, M., Liu, W., Odell, I., Ruvkun, G., and Lee, S.S. 2005. A systematic RNAi screen for longevity genes in C. elegans. Genes & Dev. 19: 1544–1555.

Hansen, M., Hsu, A.L., Dillin, A., and Kenyon, C. 2005. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 1: e17. doi: 10.1371/journal.pgen.0010017.

Rogina, B., Reenan, R.A., Nilsen, S.P., and Helfand, S.L. 2000. Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 290: 2137–2140.

Walker, D.W., Hajek, P., Muffat, J., Knoepfle, D., Cornelison, S., Attardi, G., and Benzer, S. 2006. Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc. Natl. Acad. Sci. 103: 16382–16387

Dillin, A., Crawford, D.K., and Kenyon, C. 2002. Timing requirements for insulin/IGF-1 signaling in C. elegans. Science 298: 830–834.

Zou, S., Meadows, S., Sharp, L., Jan, L.Y., and Jan, Y.N. 2000.Genome-wide study of aging and oxidative stress response in Drosophila melanogaster. Proc. Natl. Acad. Sci. 97: 13726–13731.

Lund, J., Tedesco, P., Duke, K., Wang, J., Kim, S.K., and Johnson, T.E. 2002. Transcriptional profile of aging in C. elegans. Curr. Biol. 12: 1566–1573.

Pletcher, S.D., Macdonald, S.J., Marguerie, R., Certa, U., Stearns, S.C., Goldstein, D.B., and Partridge, L. 2002. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr. Biol. 12: 712–723.

Landis, G.N., Abdueva, D., Skvortsov, D., Yang, J., Rabin, B.E., Carrick, J., Tavare, S., and Tower, J. 2004. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc. Natl. Acad. Sci. 101: 7663–7668.

Wang, H.D., Kazemi-Esfarjani, P., and Benzer, S. 2004. Multiple-stress analysis for isolation of Drosophila longevity genes. Proc. Natl. Acad. Sci. 101: 12610–12615.

Kim, S.N., Rhee, J.H., Song, Y.H., Park, D.Y., Hwang, M., Lee, S.L., Kim, J.E., Gim, B.S., Yoon, J.H., Kim, Y.J., et al. 2005. Age-dependent changes of gene expression in the Drosophila head. Neurobiol. Aging 26: 1083–1091.

Girardot, F., Lasbleiz, C., Monnier, V., and Tricoire, H. 2006. Specific age related signatures in Drosophila body parts transcriptome. BMC Genomics 7: 69. doi: 10.1186/1471-2164-7-69.

Fraser, H.B., Khaitovich, P., Plotkin, J.B., Paabo, S., and Eisen, M.B. 2005. Aging and gene expression in the primate brain. PLoS Biol. 3: e274. doi: 10.1371/journal.pbio.0030274.

Zahn, J.M., Sonu, R., Vogel, H., Crane, E., Mazan-Mamczarz, K., Rabkin, R., Davis, R.W., Becker, K.G., Owen, A.B., and Kim, S.K. 2006. Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet. 2: e115. doi: 10.1371/journal.pgen.0020115.eor.

Golden, T.R. and Melov, S. 2004. Microarray analysis of gene expression with age in individual nematodes. Aging Cell 3: 111–124.

McCarroll, S.A., Murphy, C.T., Zou, S., Pletcher, S.D., Chin, C.S., Jan, Y.N., Kenyon, C., Bargmann, C.I., and Li, H. 2004. Comparing genomic expression patterns across species identifies shared transcriptional profile in aging. Nat. Genet. 36: 197–204.

Tags: aging, signatures