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Hydroxymethylation at promoter region is associated with a release of methyl-binding proteins and an increase in transcription [38,43]. Methylation in the gene body is a feature of actively transcriped genes [44,45]. IGF2 enhancer, an aging regulator. crotonylation[61]. centenarian DNA has a lower methylation content covering all genimc regions [71,72]. DR cause DNA methylation changes in genes linked to aging including TNF-alpha, and TFs such as WT1. In Rehsus macaque brain there is an age-related global increase in H3K4me2, associated with transcriptionally active sites, at both promoter and enhancer regions [111]. A modifier regulting H£K36me3 affects lifepsan in C. elegans [161]. Tags: Edit this page |
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