Denigma Buck Institute Health Extension

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polymorphism factor odds ratio pvalue initial number replication number Population age of cases shorter lived allele longer lived allele study type reference
KIR2DS3 haplotypes KIR2DS3 — 0.05 100 vs 100 — Irish Age range: 65-99 — — Candidate Region/Gene 21299522
rs3772190 TERC — 0.006 1013 total — Danish — A G Candidate Region/Gene 22136229
rs12696304 TERC — 0.248 1013 total — Danish — — — Candidate Region/Gene 22136229
ACE genotype ACE — 0.716 102 vs 7232 — Korean Mean age 102 — — Candidate Region/Gene 12634288
rs1800775 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years CC non-CC Candidate Region/Gene 23083790
rs708272 CETP — 0.02 10261 — Danish 20-93, followed for up to 34 years GG non-GG Candidate Region/Gene 23083790
rs2060793 CYP2R1 — 0.04 1038 (offspring of nonagenarians who had at least one nonagenarian sibling) vs 461 (offsprings' partners) — Dutch Males: >/= 89; Females: >/= 91 — — Candidate Region/Gene 23128285
rs2060793 CYP2R1 — 0.04 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) A — Candidate Region/Gene 23128285
rs2282679 GC — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs3829251 NADSYN1 — 0.6 1038 vs 461 — Dutch 59.5 years (offspring of nonagerians) — — Candidate Region/Gene 23128285
rs2107538 RANTES 3.20 0.029 104 vs 110 — Spaniard Mean age 89.4 A G Candidate Region/Gene 22265023
rs2280789 RANTES 8.80 0.03 104 vs 110 — Spaniard Mean age 89.5 C T Candidate Region/Gene 22265023
rs2107538-rs2280789 RANTES — 0.04 104 vs 110 — Spaniard Mean age 89.6 non G-C haplotypes G-C Candidate Region/Gene 22265023
rs2107538-rs2280789 RANTES 4.90 0.03 104 vs 110 — Spaniard Mean age 89.6 non A-T haplotypes A-T Candidate Region/Gene 22265023
rs1544410-rs17878969 VDR 15.30 0.001 104 vs 114 — Caucasian, Spaniard >85 non G-S haplotypes G-S Candidate Region/Gene 20407924
rs11568820-rs4516035-rs10735810-rs1544410-rs17878969 VDR 11.50 0.024 104 vs 114 — Caucasian, Spaniard >85 G-G-C-G-S non G-G-C-G-S haplotypes Candidate Region/Gene 20407924
APOE4 APOE — 0.71 106 vs 349 — American 70-79 (duration of study - 7 years) e4 — Candidate Region/Gene 16799145
rs1937 TFAM — 0.003 107 vs 284 — Spaniard 100–111 G CC (genotype) Candidate Region/Gene 23186209
HP 1/2 HP 1.27 0.0194 1072 total — Italian >88 HP*2 HP*1 Candidate Region/Gene 21147083
HP*1 F/S HP 0.82 0.33 1072 total — Italian >88 — — Candidate Region/Gene 21147083
rs1801133 MTHFR — 0.01 108 (patients with CVD) vs 118 — Swiss >65 C — Candidate Region/Gene 10583447
HMOX1 (GT)_n repeats HMOX1 0.56 0.0027 108 vs 154 — Japanese Mean age 80.5 33 < repeats — Candidate Region/Gene 12566526
rs2234693 - rs2234693 ESR1 — 0.12 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
rs9340799 ESR1 — 0.22 108 vs 85 — Italian 90+ — — Candidate Region/Gene 20819792
rs4646 CYP19 1.90 0.04 108 vs 85 — Italian 90+ — T Candidate Region/Gene 20819792