Symbol: SIRT1
Name: sirtuin 1
Entrez gene ID: 23411
Ensembl gene ID: ENSG00000096717
Species: Human (Taxid: 9606)


Observation:

SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs3758391 1.0 [16257164]
  • rs1885472 1.0 [16257164]
  • rs2273773 1.0 [16257164]
  • rs10997870 1.0 [16257164]
  • rs2234975 1.0 [16257164]
  • rs7896005 0.0056 [21972126]
  • rs7069102 0.84 [18765803]
  • rs10823112 0.44 [18765803]
  • rs1885472 0.71 [18765803]
  • rs3758391 0.026 [20633545]
  • rs4746720 0.022 [20633545]
  • rs3758391 0.026 [20633545]
  • rs7896005 0.003 [21972126]
  • rs12778366 0.025 [23505545]
  • rs4746720 0.0001 [23450480]
  • rs3758391 1.0 [23450480]
  • rs3740051  1.0 [23450480]
  • rs2273773 1.0 [23450480]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • Type:
  • Gene
  • Protein coding

    References:
  • 16257164: Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity.
  • 21972126: Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.
  • 18765803: FOXO3A genotype is strongly associated with human longevity.
  • 20633545: SIRT1 variants are associated with aging in a healthy Han Chinese population.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SIRT1 (9606)
  • SIRT1 (9615)
  • SIRT1 (9913)
  • Sirt1 (10090)
  • Sirt1 (10116)
  • SIRT1 (9031)
  • sirt1 (7955)
  • Sir2 (7227)
  • sir-2.1 (6239)

  • Orthologs
  • SIR2 (4932)
  • HST1 (4932)
  • sir-2.1 (6239)
  • Sir2 (7227)
  • SIR2 (4932)
  • HST1 (4932)
  • sir-2.1 (6239)
  • Sir2 (7227)
  • SIR2 (4932)

  • Inparanoids
  • ENSP00000212015 (9606)
  • ENSMUSP00000112595 (10090)
  • ENSRNOP00000000427 (10116)
  • ENSMMUP00000035809 (9544)
  • ENSP00000212015 (9606)



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