Polymorphism: rs1935949
rs1935949 ( SNPedia | 23andMe )

Location: 6q21

Factor:
- Symbol: FOXO3A
- Name: forkhead box O3
- Entrez ID: 2309
- Ensembl ID: ENSG00000118689

Factors:
  • FOXO3A forkhead box O3 ( 2309 / ENSG00000118689 )


  • Description:

    SNP is C/T. OR and p-value are for rare homozygous allele genotype

    Ethnicity: Caucasian
    Age of cases: 95.3 ± 2.2_x000D_;+M19994.5 ± 2.1_x000D_;mean 97.7, 95– 114
    Shorter lived allele: T

    Statistics
    - Number of cases/controls: 299 vs 603;279 vs 797;383 vs 363 (initial)
    - Odds ratio: 1.46
    - p-value: 0.019 [0.019]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: In 1st and 2nd Cohort, Two methods: template directed primer extension with fluorescence polarization detection (FP- TDI, AcycloPrime II detection kit, Perkin Elmer, Boston, MA, USA) (Hsu & Kwok, 2003) and SNPstream 48plex (Beckman Coulter, Fullerton

    Reference:
    19489743: Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

    Edit (Admin) | Delete