rs939915 is significantly associated with longevity in a meta-analysis. The genotypying of this marker in central Italians results in a considerable number of dropouts and the false discovery rate (q-value of 0.145) indicates that this result is not robust enough [10496068].
The investigated population consists of southern Italy (n=92 centenarians, age range 100–108 years old, mean 101.9; and n=97 controls aged 20–60 years old, mean 41.44), northern-central Italy (n=307 centenarians, age range 99–109 years old, mean 101.0; and n=352 controls aged 17–60 years old, mean 41.2), Germany (n=376 centenarians, age range 100–110 years old, mean 104.41; and 376 controls aged 60–75 years old, mean 67.52) and France (n=546 centenarians, age range 99–106 years old, mean 103.1; and 315 controls aged 18–70 years old, mean 51.2) [10496068].
Ethnicity: Italian