Denigma Buck Institute Health Extension
Polymorphism: rs1801282
rs1801282 ( SNPedia | 23andMe )

Variant Type: SNP
Location: 3p25

Factor:
- Symbol: PPARG
- Name: peroxisome proliferator-activated receptor gamma
- Entrez ID: 5468
- Ensembl ID: ENSG00000132170

Factors:
  • PPARG peroxisome proliferator-activated receptor gamma ( 5468 / ENSG00000132170 )


    • Description:

    Significance in males only. Heterozygotes for SNP had increased presence in long-lived sample.

    Ensembel notes rs1805192 as well in this location.

    Ethnicity: Caucasian
    Age of cases: 86 to 109; median age 99
    Shorter lived allele: G
    Finding: Positive

    Statistics
    - Number of cases/controls: 222 vs 250 (initial)
    - p-value: 0.035 [0.035]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: PCR restriction fragment length polymorphism. The fragments were separated on agarose gel.

    Reference:
    15236769: Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:05 p.m.

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