Denigma Buck Institute Health Extension
Polymorphism: Presence/Deletion


Location: 22q11.23

Factor:
- Symbol: GSTT1
- Name: glutathione S-transferase theta 1
- Entrez ID: 2952
- Ensembl ID: ENSG00000184674

Factors:
  • GSTT1 glutathione S-transferase theta 1 ( 2952 / ENSG00000184674 )


    • Description:

    found a statistically significant difference in the frequency of the GSTT1 deletion and the p53 genotypes: the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (p=0.008)

    Ethnicity: Italian
    Age of cases: 100.19±2.2 (95-105)

    Statistics
    - Number of cases/controls: 66 vs 150 (initial)
    - p-value: 0.2 [0.2]
    - Significant: No

    Study Design
    - Classifications: No Age Effect
    - Study type: Candidate Region/Gene
    - Technology: loaded on 3% agarose (presence/absence of PCR product)

    Reference:
    15195682: Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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