Denigma Buck Institute Health Extension
Polymorphism: APOA1-MspI-RFLP (−75)



Location: 11q23-q24

Factor:
- Symbol: APOA1
- Name: apolipoprotein A-I
- Entrez ID: 335
- Ensembl ID: ENSG00000118137

Factors:
  • APOA1 apolipoprotein A-I ( 335 / ENSG00000118137 )


    • Description:

    Allele defined as Absence/Presence of the restriction site. Signf. in males

    Ethnicity: Calabrian
    Age of cases: 81–109 (median 101)
    Shorter lived allele: A (=Absence)

    Statistics
    - Number of cases/controls: 229 vs 571 (initial)
    - p-value: 0.016 [0.016]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: MspI Restriction analysis after PCR- amplification of the DNA regions containing the restriction sites

    Reference:
    12556235: The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects.

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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