Polymorphism: -


Location: 11p15.5

Factor:
- Symbol: TH
- Name: tyrosine hydroxylase
- Entrez ID: 7054
- Ensembl ID: ENSG00000180176

Factors:
  • TH tyrosine hydroxylase ( 7054 / ENSG00000180176 )


  • Description:

    The study checked for non-random associations between mtDNA haplotypes and nuclear polymorphisms in long-lived individuals_x000D_. There wasn't cases vs control, but stratification to 3 age groups.mtDNA haplogroup and TH genptype were assigned following procedures described in De Benedictis et al., 1999 and in De Benedictis et al., 1998, respectively.

    Ethnicity: Italian
    Age of cases: 100-105 (oldest of 3 age groups, see notes)

    Statistics
    - Number of cases/controls: 202 vs 170 vs 82 (initial)
    - p-value: 0.045 [0.045]
    - Significant: Yes

    Study Design
    - Classifications: Longevity-Associated
    - Study type: Candidate Region/Gene
    - Technology: N/A

    Reference:
    11053670: Does a retrograde response in human aging and longevity exist?

    Choice: Curate
    Created: July 2, 2013, 2:47 a.m.
    Updated: Aug. 8, 2014, 1:06 p.m.

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